Published: 05 Nov 2024
Evaluation of IL 12 Gene Expression and Serum Levels of OxPL / apoB in Patients with Coronary Artery Disease
Volume 1
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Somayeh Parichehreh-Dizaji
parichehreh1365@gmail.com
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Seyed Kianoosh Hosseini
kianhoseini@tums.ac.ir
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Sepideh Borhan Dayani
Atikehborhan@gmail.com -
Hossein Maghsoudi
hossein_m2002@yahoo.com -
Farzaneh Esmaily
farzaneh.esmaily1997@gmail.com
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Mahsa M. Amoli
amolimm@tums.ac.ir
Background Atherosclerotic lesions are formed as a result of low-density lipoprotein (LDL) accumulation, which is produced by oxidizing enzymes and oxidized phospholipids (OxPL). Phospholipid oxide causes inflammation-inducing activation genes and hyper-inflammation in addition to the initiation of inflammation and expression of Th1 cytokines. Interleukin 12 (IL-12) is one of the most significant stimulants of inflammation and immune responses, among the Th1cytokines. Therefore, it may play a significant role in contributing..