Available Online: 21 May 2026
Regional Differences in Brain Tumors: Genetic Drivers and Spatial Molecular Ecology
Volume 3
The human brain exhibits pronounced regional specialization in cellular composition, gene expression, and tissue organization. Increasing evidence indicates that these spatial differences influence where brain tumors arise and how they evolve. Across tumor entities such as gliomas, meningiomas, and brain metastases, specific molecular subtypes frequently display characteristic anatomical distributions, suggesting a functional coupling between tumor genetics and regional brain microenvironments. In this mini review, we summarize recent advances in understanding..