Published: 27 Jun 2025
The Impact of Toxic Effector Molecule TagX on the Amino Acid Conformation of the Hcp1 Monohexameric Ring in Acinetobacter baumannii Type VI Secretion System Utilizing Bioinformatics Tools and an AI System
Volume 2
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Mohammad Reza Shakibaie
mr_shakibaei@kmu.ac.ir
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Samane Shakibaie
samaneshakibaie@gmail.com
Limited information is currently available regarding the contraction mechanism of the Hcp-1 hemolysin-coregulated protein within the type VI secretion system (T6SS) of Acinetobacter baumannii, particularly about the secretion of toxic effectors. This research aimed to evaluate the mechanism underlying the contraction of the Hcp1 nanotube in response to the putative toxic effector TagX protein by employing bioinformatics tools and the artificial intelligence (AI) DeepMind system. To achieve this goal, the..
