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Cancer Immunology Connect

ISSN: 3078-154X
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Special Issue

Epigenetic Regulation of Tumor Immunity

A special issue of Cancer Immunology Connect (ISSN 3078-154X).

Submission Deadline: January 31, 2026

Special Issue Editors

Varun Sasidharan Nair
Lead Guest Editor
Italian Institute of Technology (IIT), Genova, Italy

Overview and Rationale

The proposed special issue, Epigenetic Regulation of Tumor Immunity, aims to spotlight an emerging area of cancer research that meets at the intersection of tumor immunology and epigenetics. While immunotherapies have reshaped the treatment landscape across various malignancies, many patients still experience limited or transient responses. This has prompted a growing interest in the molecular mechanisms that govern tumor-immune interaction, with particular attention to the role of epigenetic modifications in shaping the immune network.

Epigenetic mechanisms, such as DNA methylation, histone modification, chromatin remodeling, and non-coding RNAs, do not alter the genetic code but profoundly influence gene expression and cellular behavior. In the context of tumor immunity, these changes can dictate how cancer cells are recognized by the immune system, how immune cells differentiate and function in the tumor microenvironment, and whether the tumor microenvironment promotes immune activation or suppression.

The objective of this special issue is to gather high-quality original research, reviews, perspectives and case studies that explore how epigenetic processes shape antitumor immune responses, contribute to immune escape, and offer potential avenues for therapeutic intervention. Submissions are encouraged that cover both fundamental mechanisms and translational applications, including integration with checkpoint inhibitors, adoptive cell therapies, epigenetic drug development, and biomarker discovery.

By bringing together voices from across immunology, oncology, molecular biology, and epigenetics, this issue seeks to foster interdisciplinary dialogue and support the development of next-generation immunotherapies that are more precise, durable, and patient-specific.

Topics of interest:

  • Epigenetic checkpoints: Modulators of tumor–immune crosstalk in the tumor microenvironment
  • Decoding the role of non-coding RNAs in immune evasion and tumor progression
  • Single cell epigenomics reveals immune heterogeneity in the tumor microenvironment
  • Histone modifiers as immune regulators: Dual roles in tumor growth and immune activation
  • Precision immunoepigenetics: Biomarkers and therapeutic targets for patient stratification
  • Chromatin dynamics in T Cell differentiation and exhaustion: Implications for cancer immunotherapy
  • Rewiring the epigenome to enhance immune checkpoint blockade: Opportunities and challenges
  • Epigenetic landscape of myeloid cells in cancer: From tolerogenic to immunostimulatory states
  • Integrating epigenetic drugs with cellular therapies: A new era of combination modalities
  • Epigenetic plasticity of tumor-infiltrating lymphocytes: Mechanisms and modulation

Target Audience

This special issue is intended for a diverse and interdisciplinary audience of researchers, clinicians, and professionals working at the intersection of immunology, oncology, and epigenetics.

Benefits of submitting by the deadline

  • No article processing charges
  • Complimentary language editing
Submit Your Paper

For further details, please contact the editorial office at: info@scifiniti.com

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