Editorial
Published: 30 Nov 2024
Preface
Volume 1
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Hanieh Yaghootkar
HYaghootkar@lincoln.ac.uk
Published: 30 Nov 2024
Volume 1
Hanieh Yaghootkar
HYaghootkar@lincoln.ac.uk
Published: 29 Nov 2024
Volume 1
Waqas S. Abdulwahhab
wqs_saad@yahoo.com
Maitha Abdulla Aljuwaied
Moza Kamil Bin Kamil Alshamsi
Mays Alrim Mustafa Al Moukdad
Sham Zain AlAbdin
Ahmed Elbarkouky
Omar El Khatib
Salahdein Aburuz
Background: Epidermolytic hyperkeratosis (EHK) formerly known as bullous ichthyosiform erythroderma, is a rare autosomal dominant inheritance condition with a prevalence ranging from 1:200,000 to 1:300,000. The underlying etiology of which is a mutation in the genes responsible for keratin proteins synthesis, primarily in KRT1 and KRT10 genes, cataloged under OMIM number 113800. The clinicopathological presentations include blistering during the neonatal period, followed by ichthyotic hyperkeratosis in childhood and adolescence. This..
Published: 05 Nov 2024
Volume 1
Somayeh Parichehreh-Dizaji
parichehreh1365@gmail.com
Seyed Kianoosh Hosseini
kianhoseini@tums.ac.ir
Sepideh Borhan Dayani
Atikehborhan@gmail.com
Hossein Maghsoudi
drhmaghsoudi@pnu.ac.ir
Farzaneh Esmaily
farzaneh.esmaily1997@gmail.com
Mahsa M. Amoli
amolimm@tums.ac.ir
Background Atherosclerotic lesions are formed as a result of low-density lipoprotein (LDL) accumulation, which is produced by oxidizing enzymes and oxidized phospholipids (OxPL). Phospholipid oxide causes inflammation-inducing activation genes and hyper-inflammation in addition to the initiation of inflammation and expression of Th1 cytokines. Interleukin 12 (IL-12) is one of the most significant stimulants of inflammation and immune responses, among the Th1cytokines. Therefore, it may play a significant role in contributing..
Published: 17 Oct 2024
Volume 1
Saeedeh Asgarbeik
saeedeh.asgarbeik@yahoo.com
Elina Smiley
Elika Esmaeilzadeh Gharehdaghi
elika.esmaeilzadeh@gmail.com
Somayeh Parichehreh-Dizaji
parichehreh1365@gmail.com
Seyed Kianoosh Hosseini
kianhoseini@tums.ac.ir
Farzaneh Esmaily
farzaneh.esmaily1997@gmail.com
Mahsa M. Amoli
amolimm@tums.ac.ir
Background: Coronary artery disease (CAD) is among the significant causes of death globally, caused by fatty deposits in blood vessel walls. Increasing evidence indicates that toll-like receptors (TLRs) are pivotal to atherosclerosis progression. The function of CD36 as a glycoprotein in atherosclerosis was also suggested. This study aimed to investigate the levels of TLR4, TLR6, and TLR7, as well as CD36 cell surface markers in CAD. Methods: This study included..
Published: 23 Sep 2024
Volume 1
Min Ding
Junfeng Shi
jfshi@wfmc.edu.cn
Yan Sun
fysunyan@sdsmu.edu.cn
Uveal melanoma (UM) is a malignant eye cancer that has a high mortality rate and is notoriously difficult to diagnose clinically. Identifying prognostic biomarkers and evaluating the tumor immune microenvironment for UM in order to improve diagnosis, treatment decisions and even overall survival for patients. The study involved a comprehensive analysis of transcriptome profiling from the TCGA-UVM project, with the aim of identifying biomarkers and exploring the relationship between the..
Published: 10 Sep 2024
Volume 1
Vikash Chandra Mishra
vikashbiotech01@gmail.com
Dinesh Chandra
dineshchandrapathak.345@gmail.com
Anoushka Raina
araina21@gmail.com
Ritu Sharma
rit.sharma97@gmail.com
Vimarsh Raina
rainavimarsh@gmail.com
Introduction: Numerous studies have concentrated on specific populations to explore the extensive polymorphism of class I and II HLA genes. This genetic diversity is crucial for various applications, such as advancing transplantation immunology, understanding genetic population patterns, and uncovering the pathways of different diseases. Objective: The objective of the present study was to determine and analyse the frequencies of class I (HLA-A, HLA-B and, HLA-C), and class II (HLA-DRB1, and..
Published: 29 Aug 2024
Volume 1
Forough Taheri
brightness_ta@yahoo.com
Nekoo Panahi
npanahi@sina.tums.ac.ir
Mahsa M. Amoli
amolimm@tums.ac.ir
Amirhossein Sangi Nasab Lahijan
Akram Goharifar
In Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS) approaches, incidental findings (IFs) or more precisely secondary findings (SFs) have indicated controversial reports. To address SFs issues, well-known guidelines have been released such as the versions of the American College of Medical Genetics and Genomics (ACMG); however, when, to whom, why, and how these SFs should be reported are the key questions that need to be addressed ethically. The..
Published: 23 Aug 2024
Volume 1
Intissar Al-Salami
intssarsalami@yahoo.com
Qasim Jawad Al-Daami
phar.qassim.jwad@uobabylon.edu.iq
Hala Saad Bash
hala.saad@uobabylon.edu.iq
Aliaa Salman Mahdy
alhindyhayder@gmail.com
Hayder Abdul-Amir Makki Al-Hindy
phar.hayder.abdul@uobabylon.edu.iq
This review was intended to attempt to establish the complex association between the endocrine system of the host and the gut microbiota. Microbial endocrinology is a relatively new field of study, which examines how microbes regulate hormonal; and affect metabolisms, immune system, and behavior responses. This is because the gut microbiome can be viewed as a virtual endocrine organ as it is involved in the synthesis of neuroactive substances as..