Volume 2

Review Article

Available Online: 13 Mar 2026

AI-Enabled Generative Design of Immune Cells and Receptors for Programmable Immunity

Volume 2

Recent advances in generative artificial intelligence have begun to redefine the practice of cell and immune engineering. By learning the statistical and structural grammar of biological systems, generative models can now design T-cell receptors, chimeric antigen receptors, and synthetic immune circuits that meet complex objectives of affinity, stability, and specificity. When integrated into automated design–build–test–learn pipelines, these models enable continuous cycles of hypothesis generation, experimental validation, and model refinement, creating..