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Evidence Synthesis in Healthcare Connect

ISSN: 3105-0123
Volumes

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Volume 1

Articles

All Articles
open-access Systematic Review

Published: 18 Mar 2026

Mpox and Varicella-Zoster Virus Coinfection in the Democratic Republic of Congo: A Systematic Review and Meta-Analysis

Volume 1

Introduction: Monkeypox (Mpox) is an endemic disease in the Democratic Republic of Congo (DRC). Despite five decades of outbreaks, gaps persist in understanding the clinical patterns of Mpox and its coinfections with varicella-zoster virus (VZV) and human immunodeficiency virus (HIV) in this high-burden setting. This systematic review and meta-analysis were conducted to synthesize data on the clinical presentation of Mpox and coinfection trends in the Democratic Republic of the Congo...

Journal: Evidence Synthesis in Healthcare Connect
open-access Systematic Review

Published: 21 Oct 2025

Prevalence of Helicobacter pylori Infection in India: A Systematic Review and Meta-Analysis

Volume 1

This study estimated the prevalence of H. pylori infection in India among adults and children with and without gastrointestinal (GI) disorders. This meta-analysis was conducted in accordance with the 2020 PRISMA guidelines and registered with PROSPERO (CRD42024597401). Scientific databases (e.g., MEDLINE, CINAHL, and Google Scholar) were searched to identify English-language articles from India presenting data on H. pylori prevalence. The quality of the included studies was assessed, and prevalence estimates..

Journal: Evidence Synthesis in Healthcare Connect
open-access Commentary

Available Online: 09 May 2026

The Mirage of Miracle Cures: Hydroxychloroquine and Ivermectin in COVID-19

Volume 1

The global coronavirus disease 2019 (COVID-19) pandemic created unprecedented urgency for effective therapeutic interventions. In the absence of specific antivirals or vaccines during the early phase, hydroxychloroquine (HCQ) and ivermectin (IVM) emerged as widely promoted candidates based on in vitro antiviral activity, theoretical mechanisms, and anecdotal reports. Both drugs rapidly entered clinical practice and national policies despite major pharmacological and methodological limitations. Large randomized controlled trials, including RECOVERY, Solidarity, TOGETHER,..

Journal: Evidence Synthesis in Healthcare Connect
open-access Systematic Review

Available Online: 17 Apr 2026

Mpox Clinical and Epidemiological Patterns in the Central African Republic: A Systematic Review and Meta-Analysis

Volume 1

This study incorporated 40 years of evidence (1984–2024) on Mpox epidemiology, vaccination, and clinical patterns in the Central African Republic (CAR), providing insights to inform targeted control strategies for this re-emerging threat. This systematic review and meta-analysis were conducted in accordance with PRISMA guidelines. Literature searches were performed using PubMed, Scopus, ScienceDirect, Web of Science, Embase, the Cochrane Library, and AJOL. A random-effects model was used to pool estimates in..

Journal: Evidence Synthesis in Healthcare Connect
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