Perspective
Published: 22 May 2026
Chrono-Adaptive Resistance Disruption (CARD): A Novel Pharmacological Framework to Address Anticancer Drug Resistance
Volume 2
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Said Salim Said
saidalriyamy67@gmail.com
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Burhani Simai
bsimai@yahoo.com
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Sabra Salim Rashid
sunda015@gmail.com
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Ahmad Makame Mwadin
ahmadmakame9@gmail.com
Drug resistance in anticancer therapy has long been a major challenge in oncology, biomedical, and pharmacological research. Despite numerous efforts targeting molecular and pathway-level mechanisms and evaluating combination therapies, current pharmacological approaches remain largely stagnant and show limited consideration of circadian variations in tumor biology and drug resistance. Growing preclinical and clinical evidence suggests that circadian rhythms fundamentally regulate drug metabolism, cellular stress, DNA repair, and adaptive resistance mechanisms. This..
