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GenoMed Connect

eISSN: 3105-3645
Volumes

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Articles

 
open-access Review Article

Available Online: 30 Sep 2026

Metabolic Reprogramming in Brain Metastases: Integrating Spatial Omics with Non-Spatial Mechanistic Evidence

Volume 3

Brain metastases (BrMs) develop within a metabolically specialized environment, where nutrient availability and interactions with neural, vascular and immune cells can influence tumor growth. Bulk and single-cell studies have identified metabolic alterations, while spatial approaches provide additional information on their regional and cellular context. This mini review examines spatial transcriptomics, proteomics and mass spectrometry imaging alongside biochemical measurements and functional studies, focusing on central carbon metabolism, glutamate-glutamine metabolism, lipid handling..

Journal: GenoMed Connect
open-access Review Article

Available Online: 31 Aug 2026

Noncoding RNA-Mediated Control of HbF Switching: From Molecular Mechanisms to Clinical Translation

Volume 3

Journal: GenoMed Connect
open-access Review Article

Published: 09 Jul 2026

Unveiling the Fourth Meningeal Layer: Implications for Brain Structure, Function, and Neurological Disease

Volume 3

Journal: GenoMed Connect
open-access Review Article

Published: 08 Jul 2026

Dynamic Virtual Tumor Cells Powered by Spatial Omics for Translational Oncology

Volume 3

Journal: GenoMed Connect
open-access Review Article

Published: 12 Jun 2026

Spatial Profiling of the Head and Neck Squamous Cell Carcinoma Microenvironment: Reshaping Our Understanding and Therapeutic Opportunities

Volume 3

Head and neck squamous cell carcinoma (HNSCC) is characterized by a highly heterogeneous tumor microenvironment (TME), which plays a critical role in disease progression and therapeutic resistance. The emergence of spatial omics and multimodal imaging approaches, including spatial transcriptomics, proteomics and metabolomics, has revolutionized the understanding of the tumor microenvironment (TME) by preserving the spatial architecture of molecular landscapes. This review synthesizes key advances enabled by spatial omics in the..

Journal: GenoMed Connect
open-access Mini-Review

Published: 11 Jun 2026

Regional Differences in Brain Tumors: Genetic Drivers and Spatial Molecular Ecology

Volume 3

The human brain exhibits marked regional specialization in cellular composition, gene expression, and tissue architecture. Growing evidence suggests that these spatial differences influence both the anatomical distribution of brain tumors and their subsequent progression. Across tumor types such as gliomas, meningiomas, and brain metastases, specific molecular subtypes frequently show characteristic anatomical distributions, suggesting a functional coupling between tumor genetics and regional brain microenvironments. In this mini review, we summarize recent..

Journal: GenoMed Connect
open-access Short Communication

Published: 25 May 2026

Y-STR Mutation Patterns in North Indian Male Relatives at 16 Loci: A Preliminary Study

Volume 3

Journal: GenoMed Connect
open-access Review Article

Published: 05 Jun 2026

Spatial Heterogeneity of TMEs in cHL and PDAC: Mechanistic Insights and Therapeutic Perspectives

Volume 3

The tumor microenvironment (TME) is a critical niche that influences tumor progression and the development of therapeutic resistance. Spatial omics technologies enable in situ investigation of cellular ecology and intercellular interactions within the TME, addressing the lack of spatial context associated with bulk and single-cell sequencing approaches. Classical Hodgkin lymphoma (cHL) and pancreatic ductal adenocarcinoma (PDAC) exhibit distinct TME characteristics: cHL is characterized by dense immune-cell infiltration accompanied by functionally..

Journal: GenoMed Connect
open-access Review Article

Published: 30 Dec 2025

Spatial Omics in Decoding Oral Squamous Cell Carcinoma Heterogeneity: Microenvironment Crosstalk and Multi-Omics Integration

Volume 2

Oral squamous cell carcinoma (OSCC) is a significant concern within head and neck cancers due to its high heterogeneity, which contributes to poor treatment outcomes and low survival rates in advanced stages. This review discusses how spatial omics methods are used to explore tumor heterogeneity in OSCC. It focuses on alterations in the cellular, molecular, and immune microenvironment, which are driven by cancer stem cells, stromal interactions, genetic instability, epigenetic..

Journal: GenoMed Connect
open-access Review Article

Published: 29 Dec 2025

A Century of Alkaptonuria: Evolving Insights into a Rare Metabolic Disorder

Volume 2

Journal: GenoMed Connect
open-access Research Article

Published: 27 Dec 2025

Effect of Conjugated siRNA-Gold Nanoparticles on Antibiotic-Resistance Integron Class I Gene

Volume 2

Journal: GenoMed Connect
open-access Research Article

Published: 18 Dec 2025

AI-Driven Machine Learning Analysis in Major Depressive Disorder (MDD): Sex-Based Variations in Oxytocin and Clinical Profiles

Volume 2

Journal: GenoMed Connect
open-access Review Article

Published: 31 Dec 2025

Origin, Evolution, and Regulation of Cancer Genes: An Overview

Volume 2

Cancer is characterized by abnormal cell proliferation in multicellular organisms. Its emergence is linked to the evolution of multicellularity billions of years ago. The “incipient cancer genes” (proto-oncogenes) presumably evolved from genes involved in cell reproduction during the evolutionary transition from unicellular to multicellular organisms. Although these incipient cancer genes initially promoted rapid cell division required for growth at specific developmental stages, their activity had to be tightly regulated to..

Journal: GenoMed Connect
open-access Editorial

Published: 03 Oct 2025

Current Insights into Pharmacogenomics of Noncoding RNAs for Cancer Therapy

Volume 2

Cancer remains a significant global health challenge, with varying incidence and mortality rates across the globe. According to the Surveillance, Epidemiology, and End Results (SEER) registry [1] and the American Cancer Society (ACS) [2], more than 2 million new cancer cases are expected in the US by 2025. Understanding the burden of disease and advancements in tailored treatments, also known as precision or personalized medicine, is crucial for improving patient..

Journal: GenoMed Connect
open-access Review Article

Published: 24 Jun 2025

Epigenetic Insights into Bladder Cancer: The Role of Urine DNA Methylation Assays: Mini Review

Volume 2

Bladder cancer remains a major global health challenge due to its high incidence, recurrence rates, and reliance on invasive diagnostic procedures. While conventional methods, such as cystoscopy and urine cytology, are considered standard, they often demonstrate limited sensitivity, particularly in detecting early-stage disease. Epigenetic alterations, particularly DNA methylation, are now recognized as critical in bladder cancer development and progression. Non-invasive urine-based DNA methylation assays have emerged as promising diagnostic and..

Journal: GenoMed Connect
open-access Research Article

Published: 23 Jun 2025

Clinical Diversity and Outcomes of Progressive Familial Intrahepatic Cholestasis Diagnosed by Whole Genome Sequencing in Pakistani Children

Volume 2

Progressive familial intrahepatic cholestasis (PFIC) is a rare group of genetic disorders that typically presents in infants and children, often progressing to end-stage liver disease. We used whole genome sequencing (WGS) for diagnosis to assess phenotypic features and outcomes in Pakistani children with different types of PFIC. The study included 116 pediatric participants with five PFIC types: PFIC1, ATP8B1 gene (n = 19); PFIC2, ABCB11 (n = 28); PFIC3, ABCB4..

Journal: GenoMed Connect
open-access Research Article

Published: 21 Apr 2025

Identification of Hub Genes and Molecular Mechanisms of Association of PCOS, Breast, and Ovarian Cancers Using an Integrated Bioinformatics Analysis

Volume 2

Background: Oxidative stress plays a crucial role in various aspects of cancer and other diseases. While reactive oxygen species (ROS) serve as key signal molecules in physiological processes for the normal functioning of the female reproductive system, they have also been implicated in pathological processes such as polycystic ovary syndrome (PCOS). Some studies have reported a significantly higher risk of endometrial cancer in women with PCOS. However, the association of..

Journal: GenoMed Connect
open-access Perspective

Published: 28 Feb 2025

Precision Medicine for Autoimmunity: From CAAR-T Cells to AI-Driven CRISPR-Based Therapies, Challenges and Perspectives

Volume 2

This manuscript examines advancements in antigen-specific immunosuppression, as well as the potential and challenges of applying gene-editing technologies to autoimmune diseases driven by autoantibodies (AAbs). Current approved treatments fail to reach long-lived plasma cells (LLPCs), which may continue secreting pathogenic AAbs after immunobiological courses in some autoimmune illnesses. New approaches, some tested in vitro and some already undergoing clinical trials, such as the chimeric autoantibody receptor (CAAR)-T cells, BiTEs, affinity..

Journal: GenoMed Connect
open-access Editorial

Published: 15 Jan 2025

The Potential of Artificial Intelligence and Machine Learning in Pharmacovigilance: An Update

Volume 2

The integration of artificial intelligence (AI) and machine learning (ML) into pharmacovigilance (PV) marks a transformative step towards enhancing drug safety and patient outcomes. With their unparalleled ability to analyze vast and complex datasets, AI/ML technologies offer unprecedented opportunities to revolutionize adverse drug event (ADE) monitoring, signal detection, and causality assessment. This editorial explores the state-of-the-art applications, key challenges, and actionable strategies to unlock the full potential of AI in..

Journal: GenoMed Connect
open-access Case Report

Published: 29 Nov 2024

Epidermolytic Hyperkeratosis Type 1 with a New Heterozygous Mutation in KRT1 Gene: A Case Report

Volume 1

Background: Epidermolytic hyperkeratosis (EHK) formerly known as bullous ichthyosiform erythroderma, is a rare autosomal dominant inheritance condition with a prevalence ranging from 1:200,000 to 1:300,000. The underlying etiology of which is a mutation in the genes responsible for keratin proteins synthesis, primarily in KRT1 and KRT10 genes, cataloged under OMIM number 113800. The clinicopathological presentations include blistering during the neonatal period, followed by ichthyotic hyperkeratosis in childhood and adolescence. This..

Journal: GenoMed Connect
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